Which Vaccines Should You Get For Long-Term Travel?

Last Updated on April 29, 2021

When you make the decision to travel to foreign countries long-term, one of the most daunting subjects to figure out is which vaccines to get.

There are some that you absolutely need, some you should get, and others you may be able to skip depending on your plans. You may even choose to get some simply for peace of mind. Navigating the system to figure out which vaccines you need for your trip can become a nightmare. Trust me, I would know. I lived it.

In my previous post, I explained how I didn’t know which vaccines I needed, where to go for them, or what they might cost despite my health insurance. In this Vaccine Guide, I will describe what I ended up getting and what other vaccines might be useful for a long-term traveler.

The Ultimate Guide to Vaccinations For Long-Term Travel

1. Do Some Background Research

Note:  I am from the United States so this information may vary depending on where you are from, which doctor you go to, and your health insurance.

A great free resource is the Centers for Disease Control and Prevention’s website. They have a main section devoted to Traveler’s Health. You can select which countries you intend to visit, select long-term travel or study abroad, and see what the recommended vaccinations are.

There is enough information there to get a rough idea of what you will need.

2. Find a Travel Doctor

Don’t Use Generic Clinics Unless Desperate

I called so many places while trying to figure out what I needed and who could give it to me in the most affordable manner. Here is what I learned. If you can find a local Travel medical doctor, go to that person. If they are affiliated with a hospital, they will have more vaccines on hand. In my case, there was a global shortage of the Yellow Fever vaccine. Not only did my Travel doctor have a yellow fever vaccine on hand when none of the local travel clinics did. Some of the other urgent care clinics were aware of the global shortage and marked up the cost of their alternative vaccines…. knowing people might have no other option and be forced to pay a premium for it out of desperation.

This post contains incidental advice that I am providing for your benefit and awareness based on my personal experience. Consult your doctor for your own professional medical advice.

3. Design An Itinerary to the Best of Your Ability

If you can narrow down the regions you might go to, travel doctors can assist you better. Some regions have strict requirements which you need to be aware of. For example, some countries will not allow you to enter without proof of vaccination if you have previously been to countries in Africa or South America with the risk of yellow fever!

This is especially important if you may enter areas with a risk of malaria.

4. Obtain Your Vaccination Records

You will need (and want) to know what you have already had. Now I am going to unleash the bio nerd within me and take you on a journey through travel-related microbiology. πŸ˜‰

But first: a quick story. While traveling on the island of Mykonos in Greece, I trapped my thumb inside a rusty metal locking mechanism on a bathroom door. In that unexpected situation, being aware that I was vaccinated for something as standard as tetanus was extremely important. While I did ultimately remember my vaccinations, I might urge you to locally save or print your records because the best part of the whole Mykonos escapade was when I tried to pull my medical records from the doctor’s office’s website but the website wouldn’t open in Greece due to flawed online security precautions.

Which travel vaccines are the most important to know about?


Spread by coughing or sneezing, diphtheria is a respiratory illness caused by bacteria that has an incubation period of fewer than 3 days. It can result in death. Diphtheria is avoided via the Tdap or DTap vaccine most Americans receive as an infant prior to entering the school system.


Tetanus is a toxin spread via spores. If you get injured, these spores can enter the wound and cause a severe infection. It causes your muscles to become rigid. Tetanus is painful and in many cases, deadly. Many Americans are vaccinated for this as infants.


Whooping cough is a highly contagious respiratory tract infection. Symptoms include a high-pitched intake of breath that sounds like “whoop!” Before a vaccine was invested, whooping cough was considered a childhood disease.


While you may have thought Polio was eradicated, there are still a few countries with risk of poliovirus! Polio is spread via contaminated food and water. It has an incubation period of 7-14 days and in most cases, there may be no symptoms. A small percentage will experience paralysis, bladder dysfunction, impaired swallowing, breathing, and speech, all of which could be fatal.

Hepatitis A

Hepatitis A virus is spread person-to-person by contaminated food and water. Countries with less hygienic sanitation practices are at greater risk. Americans may have less exposure and be at greater risk while traveling. This vaccine-preventable disease causes inflammation of the liver. Gay men are among a number of groups that this vaccination is also highly advisable to regardless of living circumstances.

Hepatitis B

Hepatitis B is spread person-to-person via infected bodily fluids such as blood. Infected medical equipment and sexual transmission are common means of infection. Symptoms include fever, rash, joint pain, and jaundice.

Yellow Fever

Yellow Fever is spread by mosquitos. The areas with a risk of yellow fever are expanding. Right now, the company that manufactures YF-VAX (the FDA-approved vaccine) is rebuilding its factory in the USA. With production at a halt, the USA is temporarily allowing the “experimental vaccine” Stamaril to be administered instead. (It isn’t actually all that “experimental” considering it is what people outside of the USA receive as a vaccine for Yellow Fever. You will need to sign a waiver though.) Vaccination offers lifelong protection.

Typhoid Fever

Typhoid is spread via contaminated food and drinks. The symptoms of typhoid include abdominal pain, constipation, diarrhea, confusion, headache, fever, and a rash. Typhoid is a type of salmonella (salmonella typhi) and it is still common in the developing world.


Rabies is advised for travelers who may spend a lot of time outdoors. Transmission occurs when someone is bitten by an infected animal via saliva. Symptoms include irritability, depression, convulsions, cardiac arrest, and confusion. There is a pre-exposure and post-exposure vaccine. In either case, if you are bit by an animal, seek help immediately. Rabies is nearly always fatal in humans. Very few exceptions to this have been documented.

Japanese Encephalitis

Japanese Encephalitis is contracted through a mosquito. These mosquitos are typically found in specific areas in Asia. Some people get Japanese Encephalitis and show no symptoms. In other people, fever, meningitis, encephalitis, and paralysis may occur. Recovery is slow and difficult. The vaccination for this tends to be very expensive.

Tick-Borne Encephalitis

Tick-borne encephalitis is spread to humans by infected ticks and parasites. It can also be spread via milk from infected animals. The TBE Flaviviridae virus causes flu-like illnesses which usually appear within 2 weeks of being bitten. The symptoms may include fever, headache, nausea, photophobia, neck stiffness, convulsions, and an altered mental state. Meningitis, encephalitis, and paralysis may occur as well.

Updated in 2021:

COVID-19 Vaccine

The coronavirus pandemic has taken the world by storm. Starting in 2019 and lasting well into 2021 and likely beyond, the coronavirus may be around for some time. Or, as much as I hate to say this, forever. If you can get access to it, you should get the coronavirus vaccine. I got Pfizer, but any of the approved ones should be perfectly fine.

Which vaccines will you need?

Thanks to my doctor, I am more or less aware of exactly what I need given the places I intend to visit. He was able to generate and print these detailed maps for me (via a subscription service called Travax) that showed exactly which areas had risks for illnesses like malaria and yellow fever.

Given that, these statements are vast generalizations but may still prove to be useful:

Tetanus is found worldwide. It survives in soil and is difficult to eradicate.
Diphtheria is found in South East Asia, South America, and parts of Africa.
Pertussis is mostly found throughout Africa and India.
Polio is mainly still found in developing countries in Asia and Africa.
Hepatitis A is present in all countries with poor sanitation & hygiene.
Hepatitis B is found in South East Asia, the Middle East, Africa, and South America.
Yellow Fever is found in Africa and South America.
Typhoid Fever is found worldwide but more common in areas contaminated with sewage.
Rabies is more common in Asia, Africa, and South America.
Japanese Encephalitis is more common following the rainy season in many Asian countries.
Tick-Borne Encephalitis is found in parts of Asia and Europe.

Does it matter when you get them?

For some, it does! Make sure you plan early enough. I would say a good rule of thumb is to see a doctor 3 months in advance if you can manage that. Booster shot requirements are common for many of the vaccines on this list. For example, you can get a Hepatitis A vaccine that protects you for 6 months to a year but you need a second shot after that for lifelong protection.

How expensive are the vaccines?

For your convenience, I will share prices from my doctor’s office. These are full price and do not indicate what you might actually pay with insurance coverage. I thought I’d have to pay full price for everything and the truth is, I paid almost nothing for the protection that I got.

I can’t stress the importance of shopping around. For example, it says here the typhoid oral vaccine is $88.00 while the typhoid injectable vaccine is $90.00. I was able to bring a prescription for the oral vaccine to a CVS pharmacy and get my vaccine for $10.00 after insurance. You might even qualify to get some for free depending on your circumstances.

Note: some of them are very expensive. Talk to the doctor about whether or not each vaccination makes sense for your plans, destinations, and health history.

How long does protection last?

Diphtheria/Tetanus/Pertussis/Polio: 10 years.
Hepatitis A: Long-term after 2nd booster shot.
Hepatitis B: 10 years.
Yellow Fever: It used to be 10 years but now it is lifelong.
Typhoid: Injectable (2 years) Oral (5 years).
Rabies Pre-Exposure: 1-2 years.
Japanese Encephalitis: 1 year.
Tick-Borne Encephalitis: 1-3 years.

Are there any side effects?

Vaccines always carry risks. Redness, pain, and swelling may occur around the injection site. However, it is possible to experience other side effects which are much rarer. With my doctor, we had one discussion that I found particularly interesting.

With typhoid, you can take a series of typhoid pills orally instead of getting a shot for protection. The oral option is also cheaper, usually. So why would anyone opt for a shot if the oral option is cheaper and less painful? Here’s the catch.

Typhoid (injectable) offers just 2 years of protection. The vaccine carries inactivated bacteria so it is relatively risk-free but you will need to get it more often.

Typhoid (oral) offers 5 years of protection. However, the oral vaccine contains an attenuated version of the live bacteria. It literally needs to stay refrigerated because of that. Some people (a small percentage) experience some minor symptoms of typhoid bacteria while taking the course of pills. It is a higher percentage of people than with the injectable variation. Most people are fine though.

Understanding Malaria

Malaria is difficult because it is a parasite spread by mosquitos. Malaria, Dengue, and Zika are all serious and sometimes fatal diseases spread via these insects. When you are bitten, the parasite enters your bloodstream and attacks red blood cells through its process of multiplication.

Malaria is present in more than 100 countries around the world. 40% of the world’s population is at risk of getting it. In Malaria countries, a trip to a doctor’s office may result in you being given anti-malarial tablets upon arrival before even being inspected. It is the first thing they do to treat you because of how common it is.

The symptoms are similar to the flu: chills, headache, muscle aches, fatigue, fever, nausea, vomiting, diarrhea, loss of red blood cells, jaundice, and anemia. The symptoms can last as long as a year. If you become ill while traveling in malaria areas or up to a year after you get back, you should seek medical attention.

There is no vaccine for malaria but there are anti-malaria tablets that can prevent you from contracting the parasite. Some of the tablets have nasty side effects like nightmares and vivid dreams so talk to your doctor about what he or she recommends.

You can also choose to wear mosquito repellants like DEET. A more effective repellant that you can find at camping stores is something called Permethrin. There are even special clothes you can wear (some manufactured with Permethrin) to repel mosquitos!

How necessary are the vaccines?

The final decision (in most cases) is up to you. It depends on whether or not you want to take the risk. Think about where you are going. Will you be in remote areas? Will you be in touristy areas? If you’re going to the woods for camping you will want to highly consider vaccines that you might not while going to major cities.

If the vaccine is affordable and accessible, I think the obvious decision is to get it. Why would you want to go on a long, amazing trip and find yourself sick for an extended period of time? That sounds awful.

My Next Steps:

The same day of my appointment, I was able to get my Hepatitis A vaccination. I already had most of the shots which turned out to be a great relief.

My doctor recommended buying and bringing allergy medicine, Imodium tablets, and other over-the-counter medications that people sometimes overlook before leaving. He gave me a prescription for an oral typhoid vaccine, yellow fever vaccine, anti-malaria tablets, and a general antibiotic in case I get sick or an upset stomach while traveling.

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Hope you found this helpful!


    1. The Rocky Safari

      Thanks for that information, Dourdan! I have heard in the past that you can find non-profits that sometimes assist in the expenses associated with these types of vaccinations. I didn’t have such luck. Very cool to hear that you were able to find one that helped with what you needed! Awesome advice! πŸ˜€

  1. A very informative post. Thank you. I remember that when I went to Burkina Faso and Nigeria 14 years ago, the requirements for a visa from both countries were quite adamant about having current inoculations for USA travelers. However, when I was with my family in Greece, I received all of the requisite protocols with only a nominal cost from the health clinic. The health providers had manuals, updated annually, that listed all required vaccinations. Naked hugs!

    1. The Rocky Safari

      You’re very welcome! Hope you found it useful and interesting to read through! Europe is usually minimal in regards of what they require. That is a vast generalization, of course. But any travel into Africa, South America, or Asia is where the requirements and recommendations tend to get more costly and complicated.

    1. The Rocky Safari

      Hmm I’ll have to double check. I was sharing what I found through personal research but it very well could be an error. I am not a doctor*. For the most accurate information, consult your travel MD.

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The Rocky Safari